The ‘NEMO’ gene (NF-kappaB essential modulator) stimulates through a protein NF KappaB which is a major transcription factor ruling inflammatory, immune and apoptic ( mechanism of cell death) processes.
It explains the inflammatory characteristics of IP first skin lesions and the skin recovery when all the cells with the mutated gene have been destroyed.

Let’s try to make it simple: The NEMO gene  runs the elaboration of numerous proteins through the medium of  a manager  (NF KB) who sends specific messages to thousands of factories in order to produce those proteins that fight inflammation, infection and so on.
For more information see the description of IP in the part ‘Research’

The gene looks like a small train with its various carriages and compartments (1-2,3,4,5…….10…etc)

The most frequent abnormality (85%) is the loss of compartments 4 to 10. It can be found in the cases of hereditary IP.